Search on: CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1 
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Descriptor English:   Cyclic Nucleotide Phosphodiesterases, Type 1 
Descriptor Spanish:   fosfodiesterasas de nucleótidos cíclicos de tipo 1 
Descriptor Portuguese:   Nucleotídeo Cíclico Fosfodiesterase do Tipo 1 
Synonyms English:   Ca CaM Phosphodiesterase
Ca(2+)-CaM-Stimulated PDE
Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase
Ca-CaM-Phosphodiesterase
Calcium Calmodulin Dependent Phosphodiesterase
Calcium Calmodulin Stimulated Cyclic AMP Phosphodiesterase
Calcium-Calmodulin-Dependent Phosphodiesterase
Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase
Calmodulin Dependent Phosphodiesterase
Calmodulin Dependent cGMP Phosphodiesterase
Calmodulin Phosphodiesterase
Calmodulin-Dependent Phosphodiesterase
Calmodulin-Dependent Phosphodiesterase 1A
Calmodulin-Dependent Phosphodiesterase 1B
Calmodulin-Dependent Phosphodiesterase 1C
Calmodulin-Dependent cGMP Phosphodiesterase
Cyclic Nucleotide Phosphodiesterase PDE1 Family
Cyclic Nucleotide Phosphodiesterases, Type 1A
Cyclic Nucleotide Phosphodiesterases, Type 1B
Cyclic Nucleotide Phosphodiesterases, Type 1C
Cyclic Nucleotide Phosphodiesterases, Type I
PDE1 Phosphodiesterases
Phosphodiesterase 1A, Calmodulin Dependent
Phosphodiesterase 1A, Calmodulin-Dependent
Phosphodiesterase 1B, Calmodulin Dependent
Phosphodiesterase 1B, Calmodulin-Dependent
Phosphodiesterase 1C, Calmodulin Dependent
Phosphodiesterase 1C, Calmodulin-Dependent
Phosphodiesterase, Calcium-Calmodulin-Dependent
Phosphodiesterase, Calmodulin-Dependent cGMP
Phosphodiesterases, PDE1
cGMP Phosphodiesterase, Calmodulin-Dependent  
Tree Number:   D08.811.277.352.640.150.100
D08.811.277.352.640.155.100
D12.644.360.008.100
D12.644.360.009.100
D12.776.476.008.100
D12.776.476.009.100
Definition English:   A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP. 
History Note English:   2008(1981) for CA++ CALMODULIN DEPENDENT CYCLIC AMP PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1986-2007, for CALMODULIN PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1981-2007, for CALMODULIN-DEPENDENT PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1984-2007 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   52676 
Unique Identifier:   D054677 

Occurrence in VHL: 		 

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